2024 Smurf2 epd0424_6

Smurf2 epd0424_6_h08

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August undefined, 2024

Web12 Feb 2024 · SMURF2 (Smad Ubiquitin Regulatory Factor 2) as a VP40 interactor. Originally identiﬁed as a negative regulator of the BMP and TGF signaling pathways, SMURF2 plays role in embryogenesis, homeostasis, and cellular differentiation, as well as carcinogenesis and human disease pathogenesis [18–21]. We go on to show by GST pulldown assays … Web2 Aug 2024 · Smurf2 as an oncogene. Smurf2 monoubiquitinates UBCH5α and forms an active complex for the degradation of the KRAS negative regulator, βTrCP. This stabilizes …

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Web21 Mar 2024 · SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with SMURF2 include Cockayne Syndrome and Breast Cancer . … WebSmurf2 as a physiological regulator of lamin A and its disease-associated mutant form progerin (LAD50), whose expression underlies the development of Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging syndrome. We show that Smurf2 directly binds, ubiquitinates, and negatively regulates the expres- asix oleh oleh khas malang

MMRRC:037888-UCD

WebSmurf2 interacts with Smad7 to suppress TGF-β-mediated liver fibrosis through the ubiquitin-dependent degradation of TβRI during the early period of liver fibrosis. … http://www.informatics.jax.org/allele/allgenoviews/MGI:5548518 Web22 Mar 2024 · 3.6. SMURF2 Has a Significant Influence on KAP1 Interactome, Regulating Its Protein Interactions and Downstream Functions in an E3 Ligase-Dependent Manner. To further investigate the impact of SMURF2 on KAP1, we then stratified the cellular interactome of KAP1 in cells expressing either active SMURF2 or its catalytically-deficient … asix patike

Smurfs in Protein Homeostasis, Signaling, and Cancer - Frontiers

USP15 regulates SMURF2 kinetics through C-lobe mediated

Web31 Mar 2024 · The tumor-suppressive role of Smurf2 was found to be associated with cell migration and EpCAM expression; hence, Smurf2 can be considered a positive biomarker of cancer stem cell-like properties. Web25 Sep 2024 · As part of a negative feedback loop SMAD7 binds to SMURF2 targeting the TGFβ receptor for degradation. Under these conditions, SMAD7 acts as a SMURF2 agonist by disrupting the intramolecular interactions within SMURF2. We demonstrate that HGF stimulates TGFβ signalling through c-SRC-mediated phosphorylation of SMURF2 resulting … asix token anangWeb5 Aug 2005 · Smurf2 residues 269-748 containing the second and third WW domains and the HECT domain was expressed in E. coli BL21 (DE3) as a poly histidine-tagged fusion using the pProEX HTa vector, whereas full-length wild-type and mutant versions of Smurf2, Smad7 and UbcH7 were expressed as GST-fusions in E. coli BL21 using the pGex4T1 … asixsetup64

"Web23 Nov 2024 · These findings imply that Smurf2 plays a novel suppressive role in BMP/Smad signaling by suppressing activated BMP/Smad signaling (Fig. 6g ). TGF-β and … " - Smurf2 epd0424_6_h08

Smurf2 epd0424_6_h08

Accurate Ensemble Prediction of Somatic Mutations with SMuRF2

WebAllele Smurf2 tm1a(EUCOMM)Wtsi. Home Genes Smurf2 Smurf2 tm1a(EUCOMM)Wtsi. Smurf2. Summary. KO first allele (reporter-tagged insertion with conditional potential) … Webreport the identiﬁcation of Smurf2, a new member of the Hect family of E3 ubiquitin ligases. Smurf2 selectively interacts with receptor-regulated Smads and preferentially targets Smad1 for ubiquitination and proteasome-mediated degradation. At higher expression levels, Smurf2 also decreases the protein levels of Smad2, but not Smad3.

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WebGateway Donor vector containing SMURF2 , part of the Target Accelerator Plasmid Collection. Depositor. Jesse Boehm, William Hahn, David Root. Article. Kim et al Cancer …

Web18 Dec 2015 · SMURF2, a significant partner for TRAF4, exhibits multifaceted functions serving as both tumor promoter and suppressor and is involved in apoptosis, metastasis, senescence, and genomic stability... WebThis mouse line originates from an ES cell clone (clone id EPD0424_6_H08) produced by either the KOMP-CSD or EUCOMM programmes. For further details on the construction of …

Web1 Nov 2011 · Mice with target-disrupted Smurf2 allele develop normally. (A) Schematic representation of the Smurf2 locus and the targeting construct.N, NotI; X, XhoI; H, HpaI; B, BamHI.(B) Illustration of Smurf2 domain map.(C) Southern blot showing WT and targeted Smurf2 alleles.The 5′ external probe is shown in (A).(D) PCR genotyping of Smurf2 … Web6 Feb 2024 · Smurf2 is overexpressed in various squamous cell carcinomas and mediates the protective ubiquitination of epidermal growth factor receptors (EGFRs), which are considered to play an important role in tumor-associated angiogenesis and may be responsible for EGFR overexpression in certain tumors. 43 As shown in the study by Kong …

WebSmurf2 (D8B8) Rabbit mAb recognizes endogenous levels of total Smurf2 protein. This antibody also cross-reacts with proteins of unknown origin at 250 and 46 kDa in some cell …

Web20 Feb 2024 · SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Coordination between osteoblasts and osteoclasts is … asiya georgiaWeb4 Apr 2024 · Smurf2, a SMAD-specific ubiquitin E3 ligase, controls TGF-β signaling proteins such as the TGF-β receptor and SMAD2/3 . Smurf2 can also bring about degradative … asiya merchantWebsuggesting that Smurf2 regulates the localization and stability of Mad2. These data indicate that Smurf2 is a novel mitotic regulator. The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint Evan C. Osmundson , 1,3 Dipankar 1Ray , 1 Finola E. Moore , Qingshen Gao , 2,4 Gerald H. Thomsen , 5,6 atari 800 wallpaperWebSmurf2 tm1b(EUCOMM)Wtsi: Name: SMAD specific E3 ubiquitin protein ligase 2; targeted mutation 1b, Wellcome Trust Sanger Institute: MGI ID: MGI:5548518: Gene: Smurf2 … atari 800 usb keyboardWebSmurf2 are two closely related members of the Nedd4 family that exert negative functions through down-regulation of Smads and membrane receptors in transforming growth fac-tor- (TGF- )andBMP4pathways(6–12).Smurfproteinsalso function in osteoblast differentiation and regulation by target-ing Runx2 and MEKK2 for degradation (13–15). In addition, asiwaju ruger mp3Web25 Mar 2013 · Expression of the E3 ubiquitin ligase, Smurf2, had the most significant effect on EZH2 protein levels compared with the other E3 ubiquitin ligases (Mdm2, Fbw7, Cbl-b, Skp2 and Smurf1), and Smurf2-mediated decrease in EZH2 was restored by the addition of a proteasome inhibitor, MG132 (Supporting Information Fig S2), suggesting that Smurf2 is … atari 800 top gamesWebStrain Detail Sheet for C57BL/6N- A tm1Brd Smurf2 tm1a(EUCOMM)Wtsi /HMmucd asiya gusa duke