Web4 apr. 2024 · Spm could affect oxidative phosphorylation which will lead to mitophagy and mitochondrial metabolism by modulating the transcriptional accessibility of genes. After Spm treatment, cellular ROS... WebAutophagy/mitophagy may play a dual role in cancer cell response to cytotoxic drugs: It may represent either (1) a cell defense or (2) a cell death mechanism (reviewed in ). To assess the role of autophagy in Dex resistance/sensitivity, we treated T-ALL cells with Dex in the presence of CQ, an autophagy-inhibiting drug (1 µM) [ 19 ].
A mitophagy-related gene signature associated with prognosis …
WebAging is the largest risk factor for most diseases and damage to our genome is a likely cause of aging. My work focuses on exploring the physiological … WebMitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process of mitophagy was first … iron bhasma
Frontiers The Nucleus/Mitochondria-Shuttling LncRNAs Functio…
WebWe characterized the interstitial fluid (IF) content of EVs using a GFP-4T1 syngeneic murine cancer model to study EVs in-transit to the draining lymph node. GFP labeling confirmed the IF EV tumor cell origin. Molecular analysis revealed an abundance of IF EV-associated proteins specifically involved in mitophagy and secretory autophagy. WebSphingolipids in Mitophagy and Cancer Subjects: Oncology Submitted by: Megan Sheridan Definition 1. Background Advancements in cancer therapies and early detection have allowed mortality rates for many cancers to drop or remain consistent over the past 30 years. The most common cancer type to afflict men is WebMetformin. 1,1-DimetHYlbiguanide. AMPK Autophagy Mitophagy Cancer Metabolic Disease Cardiovascular Disease; Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.Metformin can cross the blood-brain barrier and … port moody tankless water heater