WitrynaThe authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood … WitrynahERG activity manifests as the movement of potassium ions through a pore present in the hERG channel protein. In the heart, that potassium movement generates one of the major repolarizing currents that bring the excited cardiomyocyte to rest. Any impairment of this repolarizing current may result in life-threatening cardiac arrhythmias.

Revealing the structural basis of action of hERG potassium channel ...

Witryna30 wrz 2024 · The hERG channel current was measured by planar technology in HEK 293 cell line by the whole-cell configuration using an automated patch clamp system … Witryna8 cze 2024 · The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current for cardiac repolarization. The unique inward rectification characteristics of the hERG channel depend on the gating regulation, which involves crucial structural domains … bridlington police force

The electrophysiological effect of cannabidiol on hERG …

Witryna10 wrz 2008 · Voltage-dependent I hERG inhibition by sibutramine HCl. In order to examine the effects of sibutramine HCl on the I hERG current–voltage relationship, I hERG was activated by the application of 2 s depolarizing voltage steps at voltages between −80 and +60 mV in 10 mV increments from a holding potential of −80 mV, … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel mediates … Zobacz więcej hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Zobacz więcej A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by electron microscopy. In the laboratory the Zobacz więcej This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Zobacz więcej The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison Zobacz więcej Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem from ion channel dysfunction (so-called channelopathies) that can lead … Zobacz więcej Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment … Zobacz więcej HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Zobacz więcej WitrynaChimeric hERG Channels Containing a Tetramerization Domain are Functional and Stable. Biochemistry.. 2013-11; GJ Hausammann, MG Grutter. Department of Biochemistry, University of ZÜrich, Winterthurerstrasse 190, 8057 ZÜrich, Switzerland. Products/Services Used. Details. bridlington police station