Webdown-reg·u·la·tion. ( down-reg'yū-lā'shŭn ), Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors. Webverb. To decrease the number of cell receptors by using downregulation. Wiktionary. Advertisement.
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WebDownregulated definition based on common meanings and most popular ways to define words related to downregulated. WebMar 27, 2024 · Downregulation definition: a decrease in sensitivity , through overexposure, to a drug or other chemical caused by a... Meaning, pronunciation, translations and examples
WebBoth up- and downregulation of HR have been described in oncogenic situations, highlighting the necessity for a precise equilibrium in HR regulation. Indeed, both … WebMar 29, 2024 · Medical Definition of Downregulation. Medical Editor: Charles Patrick Davis, MD, PhD. Reviewed on 3/29/2024. Downregulation: An decrease in the number of …
Webdownregulation. ( ˌdaʊnrɛɡjʊˈleɪʃən) n. (Medicine) a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces. Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003 ... WebOne would call a gene "donw-regulated" (in response to the treatment) when the expression under treatment conditions is lower than under control conditions.
WebIn muscle cells, anabolic steroids enter the nucleus and change how much of certain proteins are made. Proteins that are involved in building muscle are upregulated, meaning the steroids ‘up’ the number of them being made. Proteins that are involved in breaking down muscle are downregulated, meaning less of them are made.
WebFeb 10, 2024 · Chronic neuroinflammation is associated with many neurodegenerative diseases, such as Alzheimer’s. Microglia are the brain’s primary immune cells, and when activated, they release various proinflammatory cytokines. Several natural compounds with anti-inflammatory and antioxidant properties, such as epigallocatechin 3 … pods waschmittelWebThis is the meaning of downregulate: downregulate (English) Verb downregulate (third-person singular simple present downregulates, present participle downregulating, simple … pods weight ticketsWebMar 27, 2024 · The number of unique genes detected in each cell. Low-quality cells or empty droplets will often have very few genes Cell doublets or multiplets may exhibit an aberrantly high gene count Similarly, the total number of molecules detected within a cell (correlates strongly with unique genes) pods weatherproofWebwww.ncbi.nlm.nih.gov pods warehouse phoenixvilleDownregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. Such an epigenetic alteration can cause expression of the RNA or protein to no longer respond to an external stimulus. This occurs, for instance, during drug addiction or progression to cancer . See more In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an … See more Elevated levels of the hormone insulin in the blood trigger downregulation of the associated receptors. When insulin binds to its receptors on … See more DNA damage appears to be the primary underlying cause of cancer. If accurate DNA repair is deficient, DNA damages tend to accumulate. Unrepaired DNA damage can increase mutational errors during DNA replication due to error-prone translesion synthesis. … See more All living cells have the ability to receive and process signals that originate outside their membranes, which they do by means of proteins called receptors, often located at the cell's surface imbedded in the plasma membrane. When such signals interact with a … See more Family-based, adoption, and twin studies have indicated that there is a strong (50%) heritable component to vulnerability to substance abuse … See more • Regulation of gene expression • Desensitization (medicine) • Addiction • Cocaine See more • Sherwood, L. (2004). Human Physiology From Cells to Systems, 5th Ed (p. 680). Belmont, CA: Brooks/Cole-Thomson Learning • Wilmore, J., Costill, D. (2004). Physiology of Sport … See more pods weight limitWebApr 9, 2024 · Definition of 'downregulate' downregulate noun to decrease the sensitivity to a drug or other chemical by reducing the number or density of receptors on cell surfaces … pods washing machineWebDefinition of Downregulation. Medical Editor: Charles Patrick Davis, MD, PhD. Reviewed on 3/29/2024. downregulation. Downregulation: An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent. For example, insulin receptors may be downregulated in type 2 diabetes. pods washington state