Cisplatin kidney function
WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, … WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al ...
Cisplatin kidney function
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WebFeb 1, 2016 · Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury. Cisplatin for injection, USP: single-dose vials containing 50 mg of Cisplatin as white to light yellow lyophilized powder for reconstitution. See more Cisplatin for injection is contraindicated in patients with severe hypersensitivity to Cisplatin [see Warnings and Precautions (5.4)]. See more
WebMar 1, 2024 · Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse renal events. However, the effect … WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investi Impact of …
WebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is … WebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with renal …
WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases.
Webcisplatin; kidney toxicity; redox imbalance; mitochondria; natural products; oxidative stress 1. Introduction Cisplatin is a widely used anti-solid tumor drug that can target a variety of cancers including those of the breast, ovary, lung, testis, head, and neck [ 1, 2, 3, 4, 5 ]. payton wheelerWebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … payton whiteWebApr 12, 2024 · GFR allows a correct assessment of kidney function in patients with cancer undergoing cisplatin therapy. Abbreviations: BSA, body surface area; CKD-EPI, chronic kidney disease epidemiology collaboration; CRF, chronic renal failure; GFR, estimated-glomerular filtration rate; FPA, furanpropanoic acid; PAH, P-Amminoippurate; uCrCl, … payton white columbia moWebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ). payton wilgar wifeWebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. payton wilkey go fund meWebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. payton williamsWebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … payton wilkerson kaitlyn cottage